| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8270995 | Free Radical Biology and Medicine | 2013 | 13 Pages |
Abstract
⺠Brain iron dyshomeostasis in PD is an essential factor in the disease pathology. ⺠Brain iron accumulation involves an increase in iron-containing molecules. ⺠Iron induces oxidative stress. ⺠Iron induces α-synuclein aggregation and accumulation. ⺠Natural and chimeric iron chelators display potential benefits in PD animal models.
Keywords
6-OHDADFOFbxl5epigallocatechin 3-gallateIREGSHEGCGDesferrioxamineHO-16-HydroxydopamineEPOHIFHeme oxygenase-1MAOMPTPl-DOPAl-dihydroxyphenylalanineerythropoietinamyotrophic lateral sclerosisAlzheimer's diseaseALSBlood–brain barrierBBBiron-responsive elementHypoxia-inducible factormonoamine oxidaseGlutathione
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Authors
Orly Weinreb, Silvia Mandel, Moussa B.H. Youdim, Tamar Amit,