| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271020 | Free Radical Biology and Medicine | 2013 | 14 Pages |
Abstract
⺠Alzheimer disease is complicated by inappropriate compartmentalization of metals. ⺠Zn and Cu are sequestered into plaques, whereas intraneurally these metals are depleted. ⺠Dysfunction of APP and tau engenders intraneuronal iron accumulation. ⺠Drugs that modulate metals have shown promise in three clinical trials for AD.
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Authors
Scott Ayton, Peng Lei, Ashley I. Bush,