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Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis

Article ID Journal Published Year Pages File Type
8271058 Free Radical Biology and Medicine 2013 9 Pages PDF
Abstract

- Oxidative DNA damage in dysfunctional mitochondrial bioenergetics associated with the pathogenesis of Huntington's disease.
- Oxidative damage to DNA and to mitochondria in Huntington's disease.
- Oxidative DNA repair of both nuclear and mitochondrial genomes in Huntington's disease.
Keywords
ATRataxia telangiectasia mutated kinaseFEN1OGG1MMRPGC-1αBER8-OHdGNrf23-NPA3-nitropropionic acid8-hydroxydeoxyguanosineapurinic/apyrimidinicHuntington’s diseasemismatch repairbase excision repairATMNF-E2-related factor 2antioxidant response elementFlap endonuclease 1ARE
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Role of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesis
Authors
Sylvette Ayala-Peña,
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Journal
Free Radical Biology and Medicine
Journal: Free Radical Biology and Medicine
Related Categories
ATR
ataxia telangiectasia mutated kinase
FEN1
OGG1
MMR
PGC-1α
BER
8-OHdG
Nrf2
3-NPA
3-nitropropionic acid
8-hydroxydeoxyguanosine
apurinic/apyrimidinic
Huntington’s disease
mismatch repair
base excision repair
ATM
NF-E2-related factor 2
antioxidant response element
Flap endonuclease 1
ARE
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