| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271062 | Free Radical Biology and Medicine | 2013 | 10 Pages |
Abstract
⺠Oxidative stress is a key player in Parkinson disease. ⺠Oxidative damage to nucleic acids, proteins, and lipids is found in Parkinson disease. ⺠The rotenone model recapitulates macromolecule oxidative damage in Parkinson disease.
Keywords
MDAHNEVTA4-hydroxy-2-nonenalMitochondrial DNAl-DOPAO2−OH•ROSadenosine-5′-triphosphateATPOxidative damagePolyunsaturated fatty acidPUFALewy bodyParkinson diseasesubstantia nigra pars compactaDopaminemtDNAFree radicalsHydroxyl radicalRotenoneelectron transport chainSuperoxidemalondialdehydeMacromoleculesCSFCerebrospinal fluidventral tegmental areaETcReactive oxygen species
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Authors
Laurie H. Sanders, J. Timothy Greenamyre,