Parkinson disease: from pathology to molecular disease mechanisms

Article ID	Journal	Published Year	Pages	File Type
8271099	Free Radical Biology and Medicine	2013	13 Pages	PDF

Abstract

âº This review summarizes the key pathological and clinical features of Parkinson disease. âº The roles of genetics and predisposing and protective factors are highlighted. âº Currently known mechanisms of neurodegeneration are critically appraised. âº The current animal models of Parkinson disease are appraised. âº The difficulty of developing effective neuroprotective drugs when no good models exist is highlighted.

Keywords

MPTP peroxisome proliferator-activated receptor γ coactivator-1α lysosome-associated membrane protein type 2A Ubiquitin carboxyl-terminal hydrolase L1 UCH-L1 LAMP2A MAO-B GBA PGC-1α 1-methyl-4-phenylpyridinium STN PINK1 LRRK2 SNC LPS DBS 6-OHDA NMS 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-Hydroxy dopamine Mitochondrial DNA MPP+Human leukocyte antigen HLA Mitochondrial dysfunction interleukin Parkinson disease deep brain stimulation Oxidative stress substantia nigra pars compacta tumor necrosis factor-α leucine-rich repeat kinase 2 mtDNA Genes ubiquitin–proteasome system Nonmotor symptoms TNF-α lipopolysaccharide Genome-wide association studies GWAS monoamine oxidase-B Subthalamic nucleus glucocerebrosidase UPS