Antisense oligonucleotide against GSK-3Î² in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

Article ID	Journal	Published Year	Pages	File Type
8271161	Free Radical Biology and Medicine	2014	9 Pages	PDF

Abstract

(A) ICV administered antisense oligonucleotide directed at GSK-3Î² (GAO) improves learning and memory, decreases oxidative stress and tau phosphorylation, and increases Nrf2 antioxidant transcriptional activity. (B) Peripherally administered GAO crosses the blood-brain barrier (BBB).191

Keywords

Nuclear factor-E2-related factor 2 Presenilin-1 intracerebroventricularly Nrf2 GST Aβ Glycogen synthase kinase-3β (GSK-3β)NFTs ICV PS-1 GSK-3β BSA bovine serum albumin amyloid-beta Antisense Alzheimer’s disease Alzheimer’s disease (AD)Oxidative stress BBB Blood-brain barrier SAMP8 mice neurofibrillary tangles glutathione S-transferase Glycogen synthase kinase-3β

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Antisense oligonucleotide against GSK-3Î² in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

Authors

Susan A. Farr, Jessica L. Ripley, Rukhsana Sultana, Zhaoshu Zhang, Michael L. Niehoff, Thomas L. Platt, M. Paul Murphy, John E. Morley, Vijaya Kumar, D. Allan Butterfield,