Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8271234 | Free Radical Biology and Medicine | 2013 | 12 Pages |
Abstract
⺠Eupomatenoid-5 has trypanocidal activity in three parasitic forms of T. cruzi. ⺠Eupomatenoid-5 induces reduction of trypanothione reductase activity in T. cruzi. ⺠Eupomatenoid-5 induces increase in the formation of oxidant species in T. cruzi. ⺠Eupomatenoid-5 induces mitochondrial depolarization in T. cruzi. ⺠Eupomatenoid-5 induces oxidative imbalance in T. cruzi followed by parasite death.
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Authors
D. Lazarin-Bidóia, V.C. Desoti, T. Ueda-Nakamura, B.P. Dias Filho, C.V. Nakamura, S.O. Silva,