| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271260 | Free Radical Biology and Medicine | 2013 | 30 Pages |
Abstract
⺠CoMeth is a modification of the comet assay to assess O6meG levels and study MGMT activity. ⺠O6meG is converted to strand breaks by MMR-proficient cells when MGMT is inhibited. ⺠CoMeth allows the study of new MGMT inhibitors and inducers of O6meG. ⺠CoMeth allows the study of drugs that act by demethylation of MGMT or MMR genes.
Keywords
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Authors
Alice A. Ramos, Dalila F.N. Pedro, Cristovao F. Lima, Andrew R. Collins, Cristina Pereira-Wilson,