| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271318 | Free Radical Biology and Medicine | 2013 | 9 Pages |
Abstract
⺠Tadalafil protects against myocardial ischemia/reperfusion injury in diabetic mice. ⺠NADPH oxidase activity in the diabetic myocardium is attenuated by PDE-5 inhibition. ⺠Tadalafil attenuates reactive oxygen species generation and preserves ÎÏm in isolated cardiomyocytes. ⺠We report that tadalafil treatment attenuates oxidative stress in diabetic hearts.
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Authors
Saisudha Koka, Anindita Das, Fadi N. Salloum, Rakesh C. Kukreja,