| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271372 | Free Radical Biology and Medicine | 2013 | 11 Pages |
Abstract
⺠Advanced oxidation protein products induce cardiomyocyte death. ⺠AOPPs induce Nox2/Rac1/ROS-dependent TRAF3IP2 expression. ⺠Superoxide and hydrogen peroxide induce TRAF3IP2 expression. ⺠AOPPs activate TRAF3IP2/JNK-dependent proapoptotic signaling. ⺠TRAF3IP2 may represent a potential therapeutic target.
Keywords
GFPCD36CuZnSODIκBAOPPAP-1MSAIKKc-jun amino-terminal kinasem.o.i.JnkGp91phoxLPSNF-κBDPI3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideIκB kinaseMTTmouse serum albumincluster determinant 36diphenylene iodoniumAgedominant negativenuclear factor κBlipopolysaccharidecopper/zinc superoxide dismutaseinhibitory κBactivator protein-1green fluorescent proteinC-reactive proteinCRPadvanced oxidation protein productadvanced glycation end productmultiplicity of infection
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Authors
Anthony J. Valente, Tadashi Yoshida, Robert A. Clark, Patrice Delafontaine, Ulrich Siebenlist, Bysani Chandrasekar,