| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271387 | Free Radical Biology and Medicine | 2013 | 11 Pages |
Abstract
⺠H2O2 induces contraction of coronary arteries depending on the arterial size and membrane polarization. ⺠Contraction response to H2O2 is endothelium-dependent and mediated by COX and thromboxane A2 receptor. ⺠O2â production and activation of NADPH oxidase are involved in H2O2 vasoconstriction. ⺠H2O2 contraction involves [Ca2+]i increase and activation of non-L-type and L-type Ca2+ channels. ⺠MAP and Rho kinases are implicated in H2O2 coronary vasoconstriction.
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Authors
Elvira Santiago, Cristina Contreras, Albino GarcÃa-Sacristán, Ana Sánchez, Luis Rivera, Belén Climent, Dolores Prieto,