Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8271393 | Free Radical Biology and Medicine | 2013 | 35 Pages |
Abstract
⺠Lipophilic conjugates greatly enhance the neuroprotective capacity of DFOB. ⺠They are more protective against iron-mediated paraquat and H2O2 toxicity in neuronal cells. ⺠They are more protective in iron-loaded, GSH-depleted, or A30P-α-synuclein-expressing cells.
Keywords
FACL-buthionine sulfoximineBSOMAOMPTP1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideICP–MSMTTHydrogen peroxideIronFerric Ammonium CitrateParkinson diseaseOxidative stressDesferrioxamine BFree radicalsBlood–brain barrierBBBinductively coupled plasma–mass spectrometrymonoamine oxidaseParaquatChelatorclioquinol
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Authors
Jeffrey R. Liddell, Daniel Obando, Joe Liu, George Ganio, Irene Volitakis, Su San Mok, Peter J. Crouch, Anthony R. White, Rachel Codd,