| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271393 | Free Radical Biology and Medicine | 2013 | 35 Pages |
Abstract
⺠Lipophilic conjugates greatly enhance the neuroprotective capacity of DFOB. ⺠They are more protective against iron-mediated paraquat and H2O2 toxicity in neuronal cells. ⺠They are more protective in iron-loaded, GSH-depleted, or A30P-α-synuclein-expressing cells.
Keywords
FACL-buthionine sulfoximineBSOMAOMPTP1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideICP–MSMTTHydrogen peroxideIronFerric Ammonium CitrateParkinson diseaseOxidative stressDesferrioxamine BFree radicalsBlood–brain barrierBBBinductively coupled plasma–mass spectrometrymonoamine oxidaseParaquatChelatorclioquinol
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Jeffrey R. Liddell, Daniel Obando, Joe Liu, George Ganio, Irene Volitakis, Su San Mok, Peter J. Crouch, Anthony R. White, Rachel Codd,