| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271405 | Free Radical Biology and Medicine | 2013 | 11 Pages |
Abstract
⺠Sirtuins deacetylate important transcription factors that adjust the redox balance. ⺠Sirtuin-mediated protein stabilization was readily related to housekeeping and redox regulation. ⺠Sirtuins are able to alter the progress of aging. ⺠Adaptation to caloric restriction and physical exercise involves sirtuin-regulated pathways.
Keywords
DSBeNOSBERIL-1βperoxisome proliferator-activated receptor γ coactivator 1αeIF2αPIG3PGC-1αAPE1NAMPTPARP1MST1Sirt1OGG1apurinic/apyrimidinic endonuclease 1NAD+Noxainterleukin 1βDNA base excision repairendothelial nitric oxide synthaseDNA double-strand breakeukaryotic initiation factor 2αFoxOcaloric restrictionnicotinamide adenine dinucleotidenicotinamide phosphoribosyltransferasemammalian sterile 20-like kinase 1Poly(ADP-ribose) polymerase 1
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Zsolt Radak, Erika Koltai, Albert W. Taylor, Mitsuru Higuchi, Shuzo Kumagai, Hideki Ohno, Sataro Goto, Istvan Boldogh,