| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271441 | Free Radical Biology and Medicine | 2013 | 13 Pages |
Abstract
⺠Loss of p53 in stromal fibroblasts upregulates eNOS and increases NO and RNS production. ⺠Elevated NO and RNS in the fibroblasts upregulates ICAM1, promoting epithelial cell invasion. ⺠Knocking down eNOS in the fibroblasts suppresses ICAM1 synthesis and prevents epithelial invasion. ⺠Suppressing NO and RNS with antioxidant blocks ICAM1 synthesis and prevents epithelial invasion. ⺠Modulation of redox signaling in stroma may be a novel strategy to prevent epithelial invasion.
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Authors
Dunyaporn Trachootham, Gang Chen, Wan Zhang, Weiqin Lu, Hui Zhang, Jinsong Liu, Peng Huang,