| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271486 | Free Radical Biology and Medicine | 2013 | 9 Pages |
Abstract
⺠Dietary nitrite triggers the formation of nitrating species in the acidic gastric lumen. ⺠Pepsinogen is nitrated in vivo in the stomach by dietary nitrite. ⺠The nitrating dynamics depends on the physiological status of the gastric mucosa. ⺠Pepsin is nitrated by a nitrite-dependent pathway at acidic pH. ⺠Nitration decreases pepsin function, preventing the progression of gastric ulcers.
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Authors
Bárbara S. Rocha, Bruno Gago, Rui M. Barbosa, Jon O. Lundberg, Giovanni E. Mann, Rafael Radi, João Laranjinha,