| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271524 | Free Radical Biology and Medicine | 2013 | 12 Pages |
Abstract
⺠Many mitochondrial proteins were nitrated after acetaminophen (APAP) exposure. ⺠Nitrated proteins were purified and their identities determined by mass spectrometry. ⺠Nitrated mitochondrial proteins exhibited decreased activity. ⺠N-acetylcysteine prevented APAP-induced mitochondrial protein nitration. ⺠Protein nitration correlated with decreased activity and hepatotoxicity.
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Authors
Mohamed A. Abdelmegeed, Sehwan Jang, Atrayee Banerjee, James P. Hardwick, Byoung-Joon Song,