Article ID Journal Published Year Pages File Type
8271624 Free Radical Biology and Medicine 2013 9 Pages PDF
Abstract
► CNS injury causes oxidative damage and production of toxic aldehydes, such as 4-hydroxynonenal (4-HNE). ► Mitochondria are susceptible to 4-HNE, which inhibits respiration. ► Nrf2-ARE mediate the antioxidant defense enzymes. ► Nrf2-ARE activators sulforaphane and carnosic acid attenuate 4-HNE mitotoxicity.
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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo
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