Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8271633 | Free Radical Biology and Medicine | 2013 | 11 Pages |
Abstract
⺠Targeting LV reactive oxygen species upregulation attenuates type 1 diabetic cardiomyopathy. ⺠Coenzyme Q10 blunted cardiac NADPH oxidase and oxidative stress. ⺠Cardiac remodeling, dysfunction, and inflammatory markers were similarly attenuated. ⺠Coenzyme Q10 effectively limits the cardiac complications of type 1 diabetes.
Keywords
MDACoQLVEDPLVESDLVEDdANPB-cell lymphoma 2 proteinBcl2STZCTGFACE-IH&EROSangiotensin-converting-enzyme inhibitorstreptozotocininflammationBaxLeft ventricularDiabetesApoptosisFree radicalsdeceleration timeSuperoxidetibia lengthDiastolic functionConnective tissue growth factorFibrosisCardiomyocytemalondialdehydeHematoxylin and EosinHypertrophyHeart weightBCL2-associated X proteinatrial natriuretic peptideCoenzyme Q10Reactive oxygen species
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Authors
Karina Huynh, Helen Kiriazis, Xiao-Jun Du, Jane E. Love, Stephen P. Gray, Karin A. Jandeleit-Dahm, Julie R. McMullen, Rebecca H. Ritchie,