| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271635 | Free Radical Biology and Medicine | 2013 | 12 Pages |
Abstract
⺠We propose that endothelial KCa3.1 is dysfunctional in the preeclamptic vasculature. ⺠NADPH oxidase 2 is involved in the downregulation of KCa3.1 in endothelial cells. ⺠NADPH oxidase 2-induced superoxide inhibits endothelial KCa3.1 in preeclampsia. ⺠KCa3.1 dysfunction explains the vasculopathy in preeclampsia.
Keywords
HUVECX/XOtBHPtert-butylhydroperoxideNOxROSApocyninNADPH oxidaseLOXNormal pregnancyDihydroethidineFree radicalsoxygen radicalsHuman umbilical vein endothelial cellVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)HypertensionKnockdownDHECa2+-activated K+ channelReactive oxygen species
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Authors
Shinkyu Choi, Ji Aee Kim, Hye-Young Na, Ji-Eun Kim, Seonghee Park, Ki-Hwan Han, Young Ju Kim, Suk Hyo Suh,