Cytoprotective Signaling Associated with Nitric Oxide Upregulation in Tumor Cells Subjected to Photodynamic Therapy-like Oxidative Stress

Article ID	Journal	Published Year	Pages	File Type
8271656	Free Radical Biology and Medicine	2013	10 Pages	PDF

Abstract

âº 5-Aminolevulinic acid (ALA)-induced protoporphyrin IX in mitochondria sensitizes tumor cells to apoptotic photokilling, which is suppressed by stress-upregulated iNOS and NO. âº Investigation of underling signaling activity revealed that stress NO positively effects survivin induction/activation, but negatively effects pro-apoptotic JNK and p38Î± activation and pro-survival p38Î² deactivation. âº These results provide insights into how tumor cell NO can antagonize photodynamic therapy.

Keywords

Jnk ALA iNOS IκB 8-Br-cGMP c-Jun-N-terminal kinase protein kinase-B 8-bromoguanosine 3′,5′-cyclic monophosphate 1400W 5-Aminolevulinic acid IκB kinase Akt Iκκ inducible nitric oxide synthase inhibitor of NF-κB