Article ID Journal Published Year Pages File Type
8271680 Free Radical Biology and Medicine 2013 14 Pages PDF
Abstract
► Hydroquinone (HQ) induces HO-1 expression in ARE-dependent transcriptional activation of Nrf-2. ► Src knockdown or deficiency strongly abrogates HO-1 expression. ► HQ enhances Src activity by binding to the sulfhydryl group of cysteine residues. ► The Cys-400 and Cys-483 of Src are target residues for HQ-induced thiolation.
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