Article ID Journal Published Year Pages File Type
8271681 Free Radical Biology and Medicine 2013 13 Pages PDF
Abstract
► Nrf2 and ARE control expression of the antiapoptotic gene Bcl-xL and cellular apoptosis. ► Nrf2 upregulation of Bcl-xL prevents apoptosis, leading to increased drug resistance. ► Nrf2 is a potential target for reducing drug resistance.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance
Authors
, ,