| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271683 | Free Radical Biology and Medicine | 2013 | 10 Pages |
Abstract
⺠Accelerated dopaminergic neurodegeneration in a patient with PINK1 P209A mutation. ⺠PINK1 P209A mutant enhanced neuronal death induced by oxidative stress. ⺠PINK1 P209A mutant inhibited the induction of HO-1 and SOD2. ⺠ERK and Akt phosphorylation was inhibited by the expression of PINK1 P209A mutant.
Keywords
PINK1phosphatase and tensin homolog on chromosome 104-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2′-amino-3′-methoxyflavoneSB203580PD98059LY294002SOD2Heme oxygenase-1SOD1HO-1TBSERKMTTAlzheimer diseaseParkinson diseaseTris-buffered salineOxidative stressPositron emission tomographyminimal essential mediumFree radicalsSODcopper–zinc superoxide dismutasemanganese superoxide dismutaselactate dehydrogenaseLDHMEMPETPtenextracellular signal-regulated kinase
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Authors
Wei-Lin Chien, Tzeng-Ruei Lee, Shih-Ya Hung, Kai-Hsiang Kang, Ruey-Meei Wu, Ming-Jen Lee, Wen-Mei Fu,