| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271688 | Free Radical Biology and Medicine | 2013 | 17 Pages |
Abstract
⺠Recombinant human S100A8 and S100A9 scavenged hypohalous oxidants in vitro. ⺠HOCl oxidation of human S100A8 in vitro generated novel oxathiazolidine derivatives. ⺠Lung tissue and sputum from asthmatics contained S100A8, oxidized S100A8, and S100A9. ⺠S100A8 and S100A9 scavenged reactive oxygen species in vivo.
Keywords
GSTS100A9TLRTOFTFArecDTTLPSS100A8ESI–MSLC–MSMS/MSROSTrifluoroacetic acidHypohalous acidsOxidizedProtein oxidationRecombinantBALFToll-like receptordithiothreitolFree radicalstime of flightMethionine sulfoxideAnti-inflammatoryliquid chromatography–mass spectrometryelectrospray ionization–mass spectrometryTandem mass spectrometryCystic fibrosislipopolysaccharideMast cellBronchoalveolar lavage fluidNitric oxideCorticosteroidglutathione S-transferaseReactive oxygen species
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Authors
Lincoln H. Gomes, Mark J. Raftery, Wei Xing Yan, Jesse D. Goyette, Paul S. Thomas, Carolyn L. Geczy,