| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271691 | Free Radical Biology and Medicine | 2013 | 13 Pages |
Abstract
⺠Ulva lactuca yielded extracts with strongest ARE activity among 30 marine algae ⺠Two new compounds, a keto-fatty acid and its amide derivative, were isolated ⺠C18 acid (1) (C18:1(n-11)) activates the Nrf2-ARE pathway in IMR-32 cells ⺠C18 acid (1) requires NRF2 and PI3K for its antioxidant activity in IMR-32 cells ⺠A C18 acid (1)-containing Ulva extract induced ARE-regulated genes in mice.
Keywords
PI3KGCLCNQO1HMOX1phorbol 12-myristate 13-acetatetert-butylhydroquinoneGCLMAP-1DemSLC7A11MUFANACGSHNrf2SPEgsta4Ulva lactucahPAPTBHQTxnrd1Cytoprotective enzymeskeap1PMAMAPKN-acetylcysteineNAD(P)H:quinone oxidoreductase 1ROSFatty acid amidesAntioxidantsSolid-phase extractionmonounsaturated fatty acidmonounsaturated fatty acidsHuman placental alkaline phosphataseThioredoxin reductase 1Oxidative stressEdible seaweedsdiethyl maleateFree radicalsnuclear factor E2-related factor 2antioxidant-response elementphosphoinositide 3-kinaseAREheme oxygenase 1activator protein-1Kelch-like ECH-associated protein 1mitogen-activated protein kinaseGlutathioneReactive oxygen species
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Authors
Rui Wang, Valerie J. Paul, Hendrik Luesch,