| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8271701 | Free Radical Biology and Medicine | 2013 | 31 Pages |
Abstract
⺠Steady-state level and site of reactive oxygen species generation dictate cellular consequences. ⺠Low level of exogenously produced H2O2 triggers G2/M arrest and cell senescence. ⺠Mitochondria-produced H2O2 induces reversible ATP drop, G1/S arrest, and senescence. ⺠RIP1 kinase inhibition blocks death induced by high level of H2O2.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Emiliano Panieri, Vladimir Gogvadze, Erik Norberg, Rithika Venkatesh, Sten Orrenius, Boris Zhivotovsky,