Involvement of ferritin heavy chain in the preventive effect of metformin against doxorubicin-induced cardiotoxicity

► Doxorubicin is an antitumoral agent with high cardiotoxicity. ► Doxorubicin cardiotoxicity is dependent on the intracellular iron pool. ► Metformin is an antidiabetic drug that exerts cardioprotective effects. ► Metformin upregulates ferritin heavy chain (FHC) in cardiac cells via NF-κB. ► FHC and NF-κB play an important role in the cardioprotective effect of metformin.