Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

Article ID	Journal	Published Year	Pages	File Type
8271714	Free Radical Biology and Medicine	2013	11 Pages	PDF

Abstract

The legend is as follows: Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation. Reactive oxygen species are generated and then participate in osteoclast differentiation. Nrf2 deficiency leads to the promotion of RANKL-induced osteoclast differentiation, most likely owing to a higher level of oxidative stress that is caused by the aberrant production of antioxidant enzymes and GSH.131

Keywords

Nrf2 AP-1 Trx TRAP TrxR Trx reductase GSSG BMM ERK RANKL NQO1 NAC GSH M-CSF NADPH TRAF TNF DPI NF-κB PBS nuclear factor of activated T cells, cytoplasmic 1 Jnk Oxidized GSH FBS MKP Srx PRX NFATc1 keap1 c-Jun N-terminal kinase MAPK MAPK phosphatase N-acetylcysteine NAD(P)H:quinone oxidoreductase 1 NOx ROS Osteoclast tartrate-resistant acid phosphatase NADPH oxidase thioredoxin minimal essential medium Diphenyleneiodonium Free radicals SOD fetal bovine serum Sulfiredoxin Superoxide dismutase Nuclear factor-erythroid 2-related factor 2 TNF receptor-associated factor antioxidant response element tumor necrosis factor nuclear factor-κB MEM bone marrow-derived macrophage macrophage colony-stimulating factor Phosphate-buffered saline Redox regulation nicotinamide adenine dinucleotide phosphate ARE activator protein-1 Kelch-like ECH-associated protein 1 mitogen-activated protein kinase Peroxiredoxin extracellular signal-regulated kinase mitogen-activated protein kinases Glutathione Reactive oxygen species receptor activator of NF-κB ligand