| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8272873 | Journal of the Neurological Sciences | 2018 | 8 Pages |
Abstract
MSS patient-derived cells exhibit increased ER stress, an activated UPR, and susceptibility to ER stress-induced death. TUDCA reduces ER stress-induced death of MSS patient-derived cells. The potential of TUDCA as a therapeutic agent for MSS could be explored further in preclinical studies.
Keywords
PDIMarinesco-Sjogren syndrome4-PBAtunicamycinMSSVPALCLCASP3UPRDEXAXBP1ATF6αTUDCAeIF2αIRE1αER stressTauroursodeoxycholic acidEBVApoptosisDexamethasonesodium phenylbutyrateLymphoblastoid cell lineendoplasmic reticulumeukaryotic translation initiation factor 2αactivating transcription factor 6αSodium valproateEpstein-Barr virusUnfolded protein responseX-box-binding protein 1Protein disulphide isomerasePERKCaspase-3
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Authors
Ayako Kashimada, Setsuko Hasegawa, Takeo Isagai, Tsuyoshi Uchiyama, Muneaki Matsuo, Motoharu Kawai, Masahide Goto, Tomohiro Morio, Yukiko K. Hayashi, Masatoshi Takagi,