| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8274977 | Journal of the Neurological Sciences | 2016 | 16 Pages |
Abstract
Higher MS relapse frequency is observed during warmer months in different regions, but evidence for an underlying immunological variation is lacking. Therefore, we investigated seasonal variations of cytokine production in relapsing-remitting MS patients. Twenty-one patients and eight controls had blood samples drawn in each season, evaluating for IL-10, IL-6, TNF-α and IFN-γ. The lowest levels of cytokine production were observed in spring samples, with a significant increase from spring to summer for most cytokines, and especially IFN-γ and TNF-α. This phenomenon may underlie the higher prevalence of clinical and subclinical MS activity observed in warmer months.
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Authors
Alfredo Damasceno, Adriel Santos Moraes, Alessandro Farias, Benito Pereira Damasceno, Leonilda Maria Barbosa dos Santos, Fernando Cendes,