| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8275071 | Journal of the Neurological Sciences | 2015 | 9 Pages |
Abstract
The anti-inflammatory and vasodilator properties of PDE4 inhibitors make them suitable for treatment of stroke and cardiovascular disease. PDE4D has recently been suggested as factor in atrial fibrillation. This review summarizes the possible function of PDE4D in the brain, heart, and vasculature. Further, association of the described SNPs, in particular, with cardioembolic stroke, is reviewed. Current findings on the PDE4D mutations suggest functionality involves an increased cardiac risk factor as well as augmented risk of atrial fibrillation.
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Authors
Carina Jørgensen, Saiqa Yasmeen, Helle K. Iversen, Christina Kruuse,