Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8275697 | Journal of the Neurological Sciences | 2015 | 8 Pages |
Abstract
Atomoxetine (ATX) is a non-stimulant selective norepinephrine reuptake inhibitor that is widely used for the treatment of attention-deficit/hyperactivity disorder (ADHD). In this study, we firstly examined neuroprotective effects of pre- or post-treatment with 15 and 30Â mg/kg ATX against ischemic damage in the gerbil hippocampal cornus ammonis 1 (CA1) region subjected to 5Â min of transient cerebral ischemia using cresyl violet staining, neuronal nuclei immunohistochemistry and Fluoro-J B histofluorescence staining. We found that only pre-treatment with 30Â mg/kg ATX protected CA1 pyramidal neurons from ischemic insult. In addition, pre-treatment with 30Â mg/kg ATX, which had neuroprotective effect against ischemic damage, distinctly attenuated the activation of astrocytes and microglia in the ischemic CA1 region compared with the vehicle-treated ischemia group by glial fibrillary acidic protein (for astrocytes) and ionized calcium-binding adapter molecule 1 (for microglia) immunohistochemistry. In brief, our present results indicate that ATX has neuroprotective effect against transient cerebral ischemic insult and that the neuroprotective effect of ATX may be closely associated with attenuated glial activation.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Joon Ha Park, Bich Na Shin, Bai Hui Chen, In Hye Kim, Ji Hyeon Ahn, Jeong-Hwi Cho, Hyun-Jin Tae, Jae-Chul Lee, Choong-Hyun Lee, Young-Myeong Kim, Yun Lyul Lee, Sung Koo Kim, Moo-Ho Won,