Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8276464 | Journal of the Neurological Sciences | 2015 | 7 Pages |
Abstract
Our results demonstrate that brain imaging abnormalities are common in OPA1 patients, even in those with normal neurological examination. Lactate peak, cerebellar and cortical atrophies are consistent with the mitochondrial dysfunction related to OPA1 mutations and might result from widespread neuronal degeneration.
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Authors
Agathe Roubertie, Nicolas Leboucq, Marie Christine Picot, Erika Nogue, Hervé Brunel, Emmanuelle Le Bars, Gael Manes, Claire Angebault Prouteau, Catherine Blanchet, Michel Mondain, Hugues Chevassus, Patrizia Amati-Bonneau, Emmanuelle Sarzi,