Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8277278 | Journal of the Neurological Sciences | 2014 | 6 Pages |
Abstract
In conclusion, both LTG and TPM significantly reduce BMD and body weight and impair mechanical strength of bone. A question arises as to the degree of dependence of the effect on the dose. Further studies are warranted to establish whether LTG and TPM may have a clinically significant effect on BMD exclusively in the model of gonadectomized rats, or whether the effect applies also in the model of gonadally intact animals, and in the respective human models.
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Authors
Julius Simko, Sona Fekete, Iveta Gradosova, Jana Malakova, Helena Zivna, Martin Valis, Vladimir Palicka, Pavel Zivny,