| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8277391 | Journal of the Neurological Sciences | 2014 | 30 Pages |
Abstract
EBV plays a fundamental role in the pathogenesis of both autoimmunity (i.e. MS) and cancer (i.e. NPC). Our patient's immunogenetic profile included HLA alleles which are associated with psoriasis (Cw*06:02), NPC (A*26:01), MS (DRB1*15:01) and increased risk of MS, in patients carrying EBV (DRB1*15:01). We made a targeted review of the literature finding data supporting an EBV-HLA interaction mechanism behind our patient's unique combination of disorders, suggesting that beyond the standard role of each factor, their combination could act as the hidden link, in initiation or/and comorbidity of autoimmunity and cancer.
Keywords
EDSScGyHuman leucocyte antigensVDRENPCHSVDNAHLALymphoproliferative disordersdesoxyribonucleic acidMRIEBVMagnetic resonance imagingSmooth muscle tumorsCNSType II diabetes mellitusBreast cancercytomegalovirusCMVcentral nervous systemCSFCerebrospinal fluidExpanded Disability Status ScaleMultiple sclerosisEpstein–Barr virusherpes simplex virusPsoriasisPuvaNasopharyngeal carcinoma
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Authors
Maria Anagnostouli, Georgios Anagnostoulis, Serafeim Katsavos, Maria Panagiotou, Evangelia Kararizou, Panagiota Davaki,