Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8279243 | Journal of the Neurological Sciences | 2013 | 6 Pages |
Abstract
We noticed significant trend to increase the CD303+ circulating the dendritic cells. This population produces large amounts of IFN-alfa. We found significant and rapid decrease in B cells and CD4+ Th cells. Our results suggest two possible ways of beneficial cladribine influence on immune system in MS. Induction of IFN-alfa producing cells and their predominance over BDCA-1+ DCs, which are associated with cytotoxic response. Additionally, cladribine could influence two populations of lymphocytes: B cells and Th lymphocytes responsible for induction of immune response against myelin antigens.
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Authors
Krystyna Mitosek-Szewczyk, Jacek Tabarkiewicz, Barbara Wilczynska, Katarzyna Lobejko, Jerzy Berbecki, Marcin Nastaj, Ewa Dworzanska, Beata Kolodziejczyk, Zbigniew Stelmasiak, Jacek Rolinski,