Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8280939 | Journal of the Neurological Sciences | 2012 | 9 Pages |
Abstract
Moderate blast triggers moderate brain injuries, elevated levels of local brain C3/C5b-9 and systemic C5b-9, increased leukocyte infiltration, unregulated tumor necrosis factor alpha (TNFα), and aquaporin-4 in rat brain cortex at 3- and 48-hour post blast. Early immune-inflammatory response to BINT involves complement and TNFα, which correlates with hippocampus and cerebral cortex damage. Complement and TNFα activation may be a novel therapeutic target for reducing the damaging effects of BINT inflammation.
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Authors
Jurandir J. Dalle Lucca, Mikulas Chavko, Michael A. Dubick, Saleena Adeeb, Michael J. Falabella, Jessica L. Slack, Richard McCarron, Yansong Li,