Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8281972 | Journal of the Neurological Sciences | 2011 | 4 Pages |
Abstract
Environment and genetic are both relevant in determining development of Multiple Sclerosis. Many epidemiological observations converge on indicating EBV infection and Vitamin D levels as major players among the environmental factors. Bacteria and bacterial products are however potent triggers of immune responses, and recent work from several laboratories indicates that the microbiota plays a prominent role in “priming” or protecting individuals for development of experimental autoimmune diseases. Here we report our recent work dealing with the role of non-pathogenic mycobacteria and their innate receptors in relapsing-remitting experimental autoimmune encephalomyelitis in the SJL mouse and in mobilization of CNS-reactive T cells. We finally discuss how bacteria are likely involved in the pathogenesis of Multiple Sclerosis, expecially with regard to their role in driving the recurring acute episodes of disease.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Chiara Nicolò, Gabriele Di Sante, Giuseppe Migliara, Maria Grazia Valentini, Alessia Piermattei, Giovanni Delogu, Francesco Ria,