Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8282490 | Journal of the Neurological Sciences | 2011 | 5 Pages |
Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease, which is characterized by progressive degeneration of spinal and bulbar innervating motor neurons. However, the underlying mechanisms of motor neuron death remain poorly understood. Several candidate disease biomarkers have been detected in cerebrospinal fluid of ALS patients. The present study analyzed various cerebral spinal fluid gas parameters in ALS patients and compared these values to controls, as well as patients with cervical spondylosis, Parkinson syndrome, and spinocerebellar degeneration. Cerebral spinal fluid pH positively correlated with the ALS functional rating scale in total and limb-type ALS patients. In addition, cerebral spinal fluid pH positively correlated with shorter disease duration (less than 22Â weeks). These results suggested that cerebral spinal fluid pH provides a biomarker for ALS and could reflect mechanisms of disease progression in ALS patients.
Keywords
MSADRPLAGDNFPSPCCAALSFRS-rCBDPBPfamilial ALSdentatorubral-pallidoluysian atrophyMultiple system atrophyCervical spondylosisamyotrophic lateral sclerosisALSParkinson's diseasefALSCorticobasal degenerationParkinson syndromeVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Glial cell line-derived neurotrophic factorProgressive supranuclear palsylactate dehydrogenaseLDHCSFCerebrospinal fluidSpastic paraplegia
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Authors
Nobutoshi Morimoto, Kentaro Deguchi, Kota Sato, Taijun Yunoki, Shoko Deguchi, Yasuyuki Ohta, Tomoko Kurata, Yoshiki Takao, Yoshio Ikeda, Tohru Matsuura, Koji Abe,