Ferrosenescence: The iron age of neurodegeneration?

Article ID	Journal	Published Year	Pages	File Type
8284659	Mechanisms of Ageing and Development	2018	65 Pages	PDF

Abstract

In this review, we take a closer look at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.

Keywords

beta-secretase 1 histone-lysine N-methyltransferase Glutathione peroxidase-4 SETDB1 GPx-4 OMM FABP3 BACE-1 ferroportin FPN IRE QSM TDP-43 IGF-1 FTD MAM p53 mTOR APP Nrf2 AEA Transferrin Mitochondrial DNA DNA damage Antioxidants Iron cognitive impairment mild cognitive impairment imm inner mitochondrial membrane mtDNA Cancer Selenium Transposable elements iron-responsive elements Mitochondria-associated membranes outer mitochondrial membrane Insulin-like growth factor nuclear factor erythroid 2-related factor 2 frontotemporal dementia Ferroptosis phosphatidylethanolamine quantitative susceptibility mapping mammalian target of rapamycin MCI fatty acid binding protein 3 tar DNA-binding protein 43 amyloid precursor protein transferrin receptor-1

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Ferrosenescence: The iron age of neurodegeneration?

Authors

Adonis Sfera, Kelsey Bullock, Amy Price, Luzmin Inderias, Carolina Osorio,