SIPS as a model to study age-related changes in proteolysis and aggregate formation

Article ID	Journal	Published Year	Pages	File Type
8284714	Mechanisms of Ageing and Development	2018	22 Pages	PDF

Abstract

Here we review characteristics of replicative and premature senescence, how to induce most frequently used senescence models and gained knowledge on age-related changes in the major proteolytic systems.

Keywords

AGEs SA β-gal stress induced premature senescence OIS HDFs SASP Mitomycin C ICAM autophagy-lysosomal pathway PML MSC DDR DOX MMC MMP ROS senescence-associated β-galactosidase Hydrogen peroxide ALP Oncogene-Induced Senescence interleukin PAI plasminogen activator inhibitor BrdU bromodeoxyuridine protein aggregates Population doubling ATM Doxorubicin Aging Mesenchymal stem cells Vascular smooth muscle cells Sips Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Senescence-associated secretory phenotype Human diploid fibroblasts Promyelocytic leukaemia Matrix metalloproteinases Advanced glycation endproducts intercellular adhesion molecule H2O2 DNA damage response Paraquat Proteolysis retinoblastoma protein Replicative senescence Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

SIPS as a model to study age-related changes in proteolysis and aggregate formation

Authors

Christiane Ott, Tobias Jung, Tilman Grune, Annika Höhn,