Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8284714 | Mechanisms of Ageing and Development | 2018 | 22 Pages |
Abstract
Here we review characteristics of replicative and premature senescence, how to induce most frequently used senescence models and gained knowledge on age-related changes in the major proteolytic systems.
Keywords
AGEsSA β-galstress induced premature senescenceOISHDFsSASPMitomycin CICAMautophagy-lysosomal pathwayPMLMSCDDRDOXMMCMMPROSsenescence-associated β-galactosidaseHydrogen peroxideALPOncogene-Induced SenescenceinterleukinPAIplasminogen activator inhibitorBrdUbromodeoxyuridineprotein aggregatesPopulation doublingATMDoxorubicinAgingMesenchymal stem cellsVascular smooth muscle cellsSipsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Senescence-associated secretory phenotypeHuman diploid fibroblastsPromyelocytic leukaemiaMatrix metalloproteinasesAdvanced glycation endproductsintercellular adhesion moleculeH2O2DNA damage responseParaquatProteolysisretinoblastoma proteinReplicative senescenceReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Christiane Ott, Tobias Jung, Tilman Grune, Annika Höhn,