Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8284735 | Mechanisms of Ageing and Development | 2017 | 12 Pages |
Abstract
Centenarians but not octogenarians up regulate the expression of miRNAs, as we previously reported. We have looked into miRNA biogenesis. We show that RNA POL II, DROSHA, EXPORTIN 5 and DICER, are up-regulated in centenarians compared with octogenarians. Furthermore, factors involved in the control of these miRNAs biogenesis genes are also up-regulated in centenarians. Therefore, the up-regulation of miRNA expression in centenarians can be explained in part because miRNA biogenesis pathway is depressed in octogenarians (ordinary aging) while it is maintained in centenarians (extraordinary aging).
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Authors
C. Borrás, E. Serna, J. Gambini, M. Inglés, J. Vina,