Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8284831 | Mechanisms of Ageing and Development | 2015 | 38 Pages |
Abstract
MARK-AGE aims at the identification of biomarkers of human aging capable of discriminating between the chronological age and the effective functional status of the organism. To achieve this, given the structure of the collected data, a proper statistical analysis has to be performed, as the structure of the data are non trivial and the number of features under study is near to the number of subjects used, requiring special care to avoid overfitting. Here we described some of the possible strategies suitable for this analysis. We also include a description of the main techniques used, to explain and justify the selected strategies. Among other possibilities, we suggest to model and analyze the data with a three step strategy:
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Enrico Giampieri, Daniel Remondini, Maria Giulia Bacalini, Paolo Garagnani, Chiara Pirazzini, Stella Lukas Yani, Cristina Giuliani, Giulia Menichetti, Isabella Zironi, Claudia Sala, Miriam Capri, Claudio Franceschi, Alexander Bürkle, Gastone Castellani,