Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8284838 | Mechanisms of Ageing and Development | 2015 | 14 Pages |
Abstract
Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing. Within the frame of the Mark-Age project, the workpackage dedicated to “markers based on proteins and their modifications” has been firstly focused on enzymatic and non-enzymatic post-translational modifications of serum proteins by carbohydrates. The second focus of the workpackage has been directed towards protein maintenance systems that are involved either in protein quality control (ApoJ/Clusterin) or in the removal of oxidatively damaged proteins through degradation and repair (proteasome and methionine sulfoxide reductase systems). This review describes the most relevant features of these protein modifications and maintenance systems, their fate during ageing and/or their implication in ageing and longevity.
Keywords
CMLN-acetylgalactosamineGalNAcLPSPBMCRAGEMSR3-DGHMGB1AGEsHDLGlcNAcMRPhigh-density lipoproteinLC-MS/MSROSProtein modificationimmunoglobulinsAgeingperipheral blood mononuclear cellsendoplasmic reticulumProteasome activatorAutofluorescencelipopolysaccharideMethylglyoxalmethionine sulfoxide reductaseMaillard reaction productsAdvanced glycation endproductsMgOBiomarkersN-acetylglucosamineHigh mobility group box 1 proteinCarboxymethyllysineGlyoxalReactive oxygen speciesReceptor for advanced glycation end products
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Valerie Vanhooren, Alexander Navarrete Santos, Konstantinos Voutetakis, Isabelle Petropoulos, Claude Libert, Andreas Simm, Efstathios S. Gonos, Bertrand Friguet,