Article ID Journal Published Year Pages File Type
8285063 Mechanisms of Ageing and Development 2012 9 Pages PDF
Abstract
► Scn5a+/− hearts showed an electrocardiographic bundle branch block. ► Epicardial activation analysis demonstrated increased late conducting components. ► This paralleled a myocardial regional fibrosis preferentially involving the RV. ► Such changes were greatest in ageing and male Scn5a+/− hearts. ► We propose a fibrotic mechanism slowing impulse conduction in ageing Scn5a+/− hearts.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/− hearts: The effects of ageing and sex
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