Age-related alterations in mesenchymal stem cells related to shift in differentiation from osteogenic to adipogenic potential: Implication to age-associated bone diseases and defects

► MSC aging is a major obstacle limiting the success of cell therapy interventions. ► MSC aging shifts the balance in favor of adipocyte differentiation than osteoblast. ► How aging makes preferential shift from osteogenic to adipogenic differentiation. ► Information from this report can be used to develop future solutions to MSC aging.