| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8285082 | Mechanisms of Ageing and Development | 2012 | 8 Pages |
Abstract
⺠We quantified age-dependent miRNA expression in the brain of two N. furzeri strains with different life-spans. ⺠Age-regulated miRNAs have interactions with MYC and/or with TP53. ⺠Three of the regulated miRNAs were previously shown to contribute to age-dependent gene regulation in the human cerebral cortex. ⺠N. furzeri age-dependent miRNA expression appears to be evolutionarily conserved. ⺠Short lifespan in GRZ could partially be due to deregulated miRNA expression.
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Authors
Mario Baumgart, Marco Groth, Steffen Priebe, Jessika Appelt, Reinhard Guthke, Matthias Platzer, Alessandro Cellerino,