| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8285086 | Mechanisms of Ageing and Development | 2012 | 12 Pages |
Abstract
⺠We isolated EP lines showing significantly longer lifespan than control flies from a large-scale preliminary screen. ⺠Forty-five EP lines from the screen and a ubiquitous daughterless (da)-Gal4 stock were isogenized to a CS10 wild-type background. ⺠By examining lifespan of these coisogenic EP lines under da-Gal4 driver, 15 longevity genes were finally identified. ⺠Some of these genes confirmed previous longevity processes, others suggest new mechanisms for the control of aging.
Keywords
NADP-dependent malate dehydrogenaseUASGeneswitchhsp70hnRNP LHeterogeneous nuclear ribonucleoprotein LDrosophila insulin-like peptidesIMDDILPsGBE1Alzheimer's diseaseParkinson's diseasesupstream activator sequenceMaximum lifespandaughterlessPars intercerebralisAgingSmoothMenMLsPeptidoglycan recognition proteinlongevity genesimmune deficiencyKIS
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Donggi Paik, Yeo Gil Jang, Young Eun Lee, Young Nam Lee, Rochelle Yamamoto, Heon Yung Gee, Seungmin Yoo, Eunkyung Bae, Kyung-Jin Min, Marc Tatar, Joong-Jean Park,