| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8285090 | Mechanisms of Ageing and Development | 2012 | 8 Pages |
Abstract
⺠Multifunctional iron chelator M30 displayed neuroprotective effects in aged mice. ⺠Reduced cerebral iron accumulation. ⺠Markedly decreased cerebral β-amyloid plaques. ⺠Caused a significant inhibition of both MAO-A and -B activities in the cerebellum. ⺠Attenuated cognitive age-related impairment.
Keywords
MPTPMAOAPPPSENDFO1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineIron chelatorROSamyotrophic lateral sclerosisAlzheimer's diseaseALSParkinson's diseaseOxidative stresstyrosine hydroxylaseDopamineAgeingSODSuperoxide dismutaseNeuroprotectionmonoamine oxidase inhibitormonoamine oxidasePresenilinamyloid precursor proteinβ-Amyloid plaquesReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Lana Kupershmidt, Tamar Amit, Orit Bar-Am, Moussa B.H. Youdim, Orly Weinreb,