| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8285109 | Mechanisms of Ageing and Development | 2012 | 7 Pages |
Abstract
⺠We mathematically model experimental data from a transgenic strain of the fungal aging model Podospora anserina. ⺠The strain overexpresses the gene for the mitochondrial superoxide dismutase. ⺠The strain is short-lived and impaired in mitochondrial functions. ⺠Our model incorporates mitochondrial quality control into reactive oxygen (ROS) generating and scavenging pathways. ⺠It is an initial systems biology approach towards a holistic understanding of aging.
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Ageing
Authors
Axel Kowald, Andrea Hamann, Sandra Zintel, Sebastian Ullrich, Edda Klipp, Heinz D. Osiewacz,